发布时间： 2015-01-12 点击数： 719
据European Heart Journal刊登的最新研究文章，童年期暴露在二手烟环境中可对儿童动脉结构造成不可逆影响。暴露于二手烟环境可导致儿童动脉壁增厚，增加其今后患心脏 病及中风等风险。来自塔斯马尼亚、澳大利亚及芬兰的研究人员表示，童年期暴露于父母双方均吸烟的二手烟环境中的人群，成年后其血管的老化程度比普通人群高 3.3年左右。
文章来源：
原文链接：http://eurheartj.oxfordjournals.org/content/early/2014/03/03/eurheartj.ehu049
原文：Exposure to parental smoking in childhood or adolescence is associated with increased carotid intima-media thickness in young adults: evidence from the Cardiovascular Risk in Young Finns study and the Childhood Determinants of Adult Health Study
作者：Seana Gall, Quan Long Huynh, Costan G. Magnussen, Markus Juonala, Jorma S.A. Viikari, Mika K?h?nen, Terence Dwyer, Olli T. Raitakari Alison Venn
Abstract
Aim Recent evidence suggests that the exposure of children to their parents’ smoking adversely effects endothelial function in adulthood. We investigated whether the association was also present with carotid intima-media thickness （IMT） up to 25 years later.
Methods and results The study comprised participants from the Cardiovascular Risk in Young Finns Study （YFS, n = 2401） and the Childhood Determinants of Adult Health （CDAH, n = 1375） study. Exposure to parental smoking （none, one, or both） was assessed at baseline by questionnaire. B-mode ultrasound of the carotid artery determined IMT in adulthood. Linear regression on a pooled dataset accounting for the hierarchical data and potential confounders including age, sex, parental education, participant smoking, education, and adult cardiovascular risk factors was conducted. Carotid IMT in adulthood was greater in those exposed to both parents smoking than in those whose parents did not smoke [adjusted marginal means: 0.647 mm ± 0.022 （mean ± SE） vs. 0.632 mm ± 0.021, P = 0.004]. Having both parents smoke was associated with vascular age 3.3 years greater at follow-up than having neither parent smoke. The effect was independent of participant smoking at baseline and follow-up and other confounders and was uniform across categories of age, sex, adult smoking status, and cohort.
Conclusions These results show the pervasive effect of exposure to parental smoking on children’s vascular health up to 25 years later. There must be continued efforts to reduce smoking among adults to protect young people and to reduce the burden of cardiovascular disease across the population.